it's obvious really...

Edward is the best brother, giving up his arm to bring Al back and almost dying a number of times to get his body back.

The one who'd even kill the whole family to protect his one little brother... (Even though that's completely psycho! O_O)
The one who DIED FOR HIS LITTLE BROTHER!!! Itas-chan!!! xD
Edward too... :D

Ed is the the best brother in anime my opinion,giving up his arm just to bring back his brother,and he always gives his brother strength to move,he's a really great older brother in my opinion,though Itachi-kun is a pretty good brother in his own way.

I don't understand how anyone can seriously choose Itachi over Ed.

Its hard...

People who don't pick Itachi obviously don't know the full story behind Itachi... Itachi sacrificed EVERYTHING for his brother. Was willing to be forever known as a criminal, just so Sasuke could live.

by far (?).