The seconde season consisted of 23 episodes and ran from September 21, 2004 to May 24, 2005.

After Lucas and Keith learn of Dan's hart-, hart attack, they return to boom heuvel and Dan decides he wants to get to know Lucas. Lucas cautiously enters into a relationship with his father. After Dan learns that Lucas has inherited his hypertrophic cardiomyopathy (HCM), the genetic defect which caused Dan's own hart-, hart attack, he convinces Lucas to verplaats in with him and pays for his medication, keeping his condition a secret. Dan also agrees to stay away from Keith and his girlfriend Jules (guest star, Maria Menounos)...