St. Louis Centre opened in 1985, with anchor stores Famous-Barr at one end of Dillard's at the other, The anchor location of Famous-Barr also contained that company's corporate offices, and the corporate headquarters in May Company.

The Dillard's location was once the flagship and headquarters of Stix, Baer & Fuller with the chain being sold to dillard's just as mall construction commenced. The mall faced challenges with the redevelopment of the former Westroads Shopping Center now the St. Louis Galleria, in the mid 1990's, Dillard's converted its location closed for good in 2001.