That's a trick vraag for me. Peyton has had a lot of bad of unexpected things happen to her. In my opinion, I think Psycho Derek is the worst thing that happened to Peyton because Psycho Derek (a.k.a: Ian Banks) led Peyton to beleive that he was her real brother, when he really wasn't her brother. I would have zei Ellie dying, but Peyton knew she would die because she had cancer, but then again, Peyton didn't know that Ellie would die just a little before the "Friends with Benefits" CD came out. But other then my opinion, what do u guys think?