She looks like a yellow Lab mix. I could see her having Pit Bull, of some type of bully breed, in her makeup, due to her heavyset build and barrel chest. As a mutt, she could have some terriër (fairly likely) of even shepherd in her lineage too...
She zei herself in one episode that she is a mutt. She appears to have pit stier in her, she even zei so herself, and definitely some labrador, due to her coloring.
It is established in several episodes that she is a mutt, but it doesn't say what breeds are in the mix. Truman: I wish I had a bloodhound. He could help me find what I lost. Martha: I'm a mutt, a mix of breeds. One could be a bloodhound.